Identification of novel agents for HIV cure or remission

Identification of novel HIV reactivation agents: towards building translational HIV Cure Research Infrastructure in Ghana

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN14372332

Enrollment

300

Registered

2021-09-14

Start date

2019-08-21

Completion date

Unknown

Last updated

2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

identification of epigenetic modifying compounds and assessing their effectiveness in reactivating HIV from latency Infections and Infestations

Interventions

An epigenetic library of compounds will be screened in vitro for their ability to reactivate HIV from latency. The most effective will be selected and evaluated in resting T cells isolated from HIV pa

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. HIV infected 2. Adults 18 years and above 3. On combination antiretroviral therapy 4. Provided informed consent

Exclusion criteria

Exclusion criteria: Not providing informed consent

Design outcomes

Primary

Measure	Time frame
Reactivation capacity of the compounds in patient resting T cells will be measured using the quantitative RT PCR method at 48 hours of incubation ex-vivo	—

Secondary

Measure	Time frame
Virologic suppression will be measured using viral load measurements with real time PCR every 3 months for 2 years	—

Countries

Ghana

Contacts

Public ContactEvelyn Yayra Bonney

ebonney@noguchi.ug.edu.gh+233 24478567

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026