Post-operative residual neuromuscular blockade Nervous System Diseases Post-operative residual neuromuscular blockade
Conditions
Interventions
Participants are allocated to one of three study cohorts based on their age (2-10 years, 18-64 years and 65+ years), which each undergo the following:
Neoromuscular monitoring
The same standard of ge
Sponsors
First Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with American Society of Anesthesiologists (ASA) physical status I-III scheduled to undergo elective surgery undergo general with muscle relaxants 2. Patients within the age groups 2-10, 18-64 and 65+ years
Exclusion criteria
Exclusion criteria: 1. Patients with muscular disorders 2. Patients with neurological deficit 3. Patient refusal to consent 4. Patients scheduled to undergo prolong surgical procedures 5. Patients with severe impaired liver and renal function 6. Infants under 2 years 7. Patients with asthma 8. Patients with diabetes mellitus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Residual neuromuscular blockade (RNMB), defined as train-of-four (TOF) ratio of less than 0.9. Moderate (TOF ratio = 0.7 but < 0.9) and severe (TOF ratio ? 0.7) PRNMB, is assessed 5 minutes to administration of cisatracurium at induction of general anesthesia, 1 minute interval after cisatracurium injection until 6 minutes and every 15 minutes in the postanesthetic care unit (PACU) until discharge. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Demographic and patient characteristics such as age, weight, sex and co-morbidities, airway obstruction, indication of surgery, anesthesia duration, time (minutes) to PACU discharge and respiratory complications during hospital admission and length of hospital admission (days) 2. Total crystalloids and colloids volume (mls), total cisatracurium (mg) and total neostigmine (mg) 3. Perioperative and PACU temperature (?) monitoring during perioperative and PACU periods 4. Peripheral oxygen saturation (SpO2) monitoring during perioperative and PACU periods 5. End tidal carbon dioxide (EtCO2) monitoring during perioperative and PACU periods 6. Heart rate, systolic, diastolic and mean arterial pressure (mmHg) monitoring during perioperative and PACU periods. 7. Bispectral index (BIS) monitoring perioperative and PACU periods | — |
Countries
China
Outcome results
None listed