Diagnosis of axillary lymph node status in primary breast cancer without a surgical procedure

Conditions

Clinically node-negative primary breast cancer Cancer Clinically node-negative primary malignant neoplasms of breast

Ida Skarping, Julia Ellbrant, Looket Dihge, Mattias Ohlsson, Linnea Huss et al. (7 authors)

Cancer Research2024-05-02

Retrospective validation study of an artificial neural network-based preoperative decision-support tool for noninvasive lymph node staging (NILS) in women with primary breast cancer (ISRCTN14341750).

Skarping I, Ellbrant J, Dihge L, Ohlsson M, Huss L, Bendahl PO, Rydén L.

2024-01-162 citations

10.1186/s12885-024-11854-1

Artificial neural network models to predict nodal status in clinically node-negative breast cancer

Looket Dihge, Mattias Ohlsson, Patrik Edén, Par‐Ola Bendahl, Lisa Rydén

BMC Cancer2019-06-2155 citations

10.1186/s12885-019-5827-6

Interventions

Current intervention as of 31/08/2021: Patients in this study are undergoing standard diagnostic work-up within the clinical pathway for breast cancer including a clinical examination, mammogram, ultr

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Current inclusion criteria as of 31/08/2021: 1. Invasive breast cancer 2. Clinically and ultrasound node-negative disease 3. Scheduled for primary surgery 4. Female _____ Previous inclusion criteria: 1. Invasive breast cancer 2. Clinically node-negative disease 3. Scheduled for primary surgery 4. Female

Exclusion criteria

Exclusion criteria: 1. Male 2. Previous ipsilateral breast or axillary surgery 3. Previous neoadjuvant therapy 4. Palpable axillary lymphadenopathy 5. No axillary staging

Design outcomes

Primary

Measure	Time frame
Current primary outcome measure as of 31/08/2021: Axillary nodal status stratified by stage N0, N1 and N2, determined from pre-operatively available clinicopathological data after surgery compared with the predictive N-status by the algorithms _____ Previous primary outcome measure: Axillary nodal status stratified by stage N0, N1 and N2, determined from pre-operatively available clinicopathological data after surgery	—

Measure

Time frame

Current primary outcome measure as of 31/08/2021: Axillary nodal status stratified by stage N0, N1 and N2, determined from pre-operatively available clinicopathological data after surgery compared with the predictive N-status by the algorithms _____ Previous primary outcome measure: Axillary nodal status stratified by stage N0, N1 and N2, determined from pre-operatively available clinicopathological data after surgery

—

Secondary

Measure	Time frame
False negative rate with negative predictive value of NPV max to 10% for prediction of N0, determined from sentinel node biopsy data after surgery	—

Countries

Sweden

Outcome results

None listed