Topic: Mental Health
Conditions
Interventions
Participants in this trial will receive 20 sessions of real or sham rTMS, with sessions taking place 5 times per week (e.g., Monday-Friday) for 4 weeks. Through mapping of the First Dorsal Interosseou
Sponsors
King's College London
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Male and female participants who are aged 18 or over 2. BMI between 14 and 18.5 kg/m2 3. Right-handed 4. Current DSM-V diagnosis of AN-Restricting type (AN-R) or AN-Binge/purging type (AN-BP) and an illness duration of 3 years or more 5. Must have completed at least one adequate previous course of eating disorder treatment (e.g. one 6-month course of specialist outpatient therapy, specialist day-care or in-patient treatment for refeeding) 6. Must have approval from treating Eating Disorders clinician or GP to participate
Exclusion criteria
Exclusion criteria: 1. Having a history of head or eye injury 2. Having a history of a neurological disease including previous seizures of any kind 3. Having metallic implants anywhere in the head or body 4. Being on a dose of any psychotropic medication that has not been stable for at least 14 days prior to participation in the study 5. Taking antipsychotic medication 6. Taking anti-convulsive medication 7. Being pregnant 8. Having a current other major psychiatric disorder (e.g., major depressive disorder, substance dependence, schizophrenia or bipolar disorder) needing treatment in its own right 9. Excessive alcohol (> 3 units per day, 5 days of the week) and/or cigarette consumption (> 15 cigarettes per day) 10. Severe abnormalities in their screening clinical blood sample 11. An rTMS safety questionnaire and an MRI safety questionnaire will also be administered and if considered not safe to deliver rTMS or undergo MRI scanning, people will subsequently be excluded on this basis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical and cognitive outcomes 1. BMI is measured with height and weight at baseline, weekly during treatment, at post-treatment, and at 3-month follow-up 2. Eating disorder symptomatology is measured with the Eating Disorders Examination Questionnaire (EDE-Q), Fear of Food Measure (FOFM), and Self-Starvation Scale at baseline, post-treatment, and 3-month follow-up. The FOFM and a short version of the EDE-Q will also be completed weekly during treatment 3. Current eating disorder experience are measured with visual analogue scales before and after each daily rTMS session 4. Other psychiatric symptomatology is measured with the Depression, Anxiety and Stress Scales (DASS), Positive and Negative Affect Schedule, Profile of Mood States, and Intolerance of Uncertainty Scale at baseline, post-treatment, and 3-month follow-up. The DASS is also completed weekly during treatment 5. Inhibitory control is measured with a proactive inhibition task at baseline, post-treatment, and 3-month follow-up 6. Attentional bias to food measured with the Visual Probe Task at baseline and post-treatment 7. Food choice behaviour is measured with the Food Choice Task at baseline and post-treatment 8. Impulsivity/compulsivity are measured with the Delaying Gratification Inventory, Barratt Impulsiveness Scale, and Obsessive-Compulsive Inventory at baseline, post-treatment, and 3-month follow-up 9. Cognitive control over emotions is measured with the Emotion Regulation Questionnaire at baseline, post-treatment, and 3-month follow-up. 10. Cognitive flexibility is measured with the Cognitive Flexibility Scale at baseline, post-treatment, and 3-month follow-up 11. Self-efficacy is measured with the Eating Disorder Recovery Self-Efficacy Questionnaire at baseline, post-treatment, and 3-month follow-up. 12. Quality of life is measured with the EuroQol Quality of Life Scale at baseline and 3-month follow-up 13. Illness impact is measured with the Clinical Impairment Assessment at baseline and 3-mont | — |
Secondary
| Measure | Time frame |
|---|---|
| There are no secondary outcome measures | — |
Countries
England, United Kingdom
Contacts
Public ContactJessica McClelland
Outcome results
None listed