Gastrointestinal dysfunction in patients with Parkinson's disease Digestive System
Conditions
Interventions
The random allocation sequence will be generated using a random number table method by a statistician not involved in the trial. Allocation sequences will be concealed in sequentially numbered, sealed
Sponsors
Beijing Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Idiopathic PD diagnosis 2. Gastrointestinal dysfunction meeting Rome IV FGIDs criteria 3. Ability to provide written informed consent 4. Men or women aged 40 to 80 years 5. Liver function, kidney function, blood routine, urine routine, and stool routine are all normal
Exclusion criteria
Exclusion criteria: 1. Gastrointestinal dysfunction caused by other diseases 2. Severe heart, liver, kidney, or other organ dysfunction 3. Have been taking gastrointestinal motility drugs and laxative drugs for a long time 4. Severe cognitive impairment and language impairment who cannot cooperate with the rating 5. Inability to adhere to the study protocol as determined by the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Gastrointestinal dysfunction is measured using the electrogastrogram at baseline and 4 weeks 2. Blood Serum Index is measured using radioimmunoassay at baseline and 4 weeks 3. Gastrointestinal dysfunction is measured using the Rome IV functional gastrointestinal disorders (FGID) criteria at baseline and 4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Stool analysis by 16S-rRNA high throughput sequencing at baseline and 4 weeks 2. The extent of Parkinson's disease is measured using the Unified Parkinson's disease rating scale (UPDRS) and the Hoehn–Yahr Rating Scale at baseline, 4, 12 and 24 weeks | — |
Countries
China
Contacts
Public ContactPanlin Cen
Outcome results
None listed