Chronotype-aligned exercise timing in middle-aged adults at cardiometabolic risk

Effects of chronotype-aligned versus chronotype-misaligned aerobic exercise on cardiovascular, metabolic, and sleep outcomes: a randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN14276441

Enrollment

150

Registered

2026-02-05

Start date

2025-01-06

Completion date

Unknown

Last updated

2026-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular risk factors in sedentary middle-aged adults (40–60 years), including prehypertension, stage 1 hypertension, overweight/obesity, impaired fasting glucose, and family history of premature cardiovascular disease. Nutritional, Metabolic, Endocrine

Interventions

Participants were randomized using computer-generated permuted blocks of size 4 and 6, stratified by chronotype (morning or evening) and cardiovascular risk level (low, moderate). Block sizes were ran

Eligibility

Sex/Gender

All

Age

40 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Age 40–60 years 2. Sedentary lifestyle (no structured physical activity =1 session/week in the past 3 months) 3. At least one cardiovascular risk factor: 4. Prehypertension or stage 1 hypertension 5. Overweight/obesity (BMI = 25 kg/m²) 6. Impaired fasting glucose 7. Family history of premature cardiovascular disease 8. Regular sleep schedules

Exclusion criteria

Exclusion criteria: 1. Clinically diagnosed cardiovascular or metabolic diseases (e.g., coronary artery disease, diabetes) 2. Night shift workers or irregular sleep schedules 3. Diagnosed sleep disorders (e.g., insomnia, obstructive sleep apnea) 4. Medications affecting cardiovascular or circadian regulation (unless stable =6 months) 5. Intermediate chronotype (Morningness-Eveningness Questionnaire score 42–58)

Countries

Pakistan

Contacts

Public ContactArsalan Tariq

at81931@gmail.com+923443186795

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 19, 2026