Early introduction of allergenic foods to induce tolerance in infants

Conditions

Food allergy, food hypersensitivity, eczema, asthma, allergic rhinitis Not Applicable

Roberts G, Bahnson HT, Du Toit G, O'Rourke C, Sever ML, Brittain E, Plaut M, Lack G.

2022-12-1241 citations

10.1016/j.jaci.2022.09.042

Early Gluten Introduction and Celiac Disease in the EAT Study

Kirsty Logan, Michael R. Perkin, Tom Marrs, Suzana Radulović, Joanna Craven et al. (8 authors)

JAMA Pediatrics2020-09-2853 citations

10.1001/jamapediatrics.2020.2893

Association of Early Introduction of Solids With Infant Sleep

Michael R. Perkin, Henry T. Bahnson, Kirsty Logan, Tom Marrs, Suzana Radulović et al. (8 authors)

JAMA Pediatrics2018-07-0941 citations

10.1001/jamapediatrics.2018.0739

Randomized Trial of Introduction of Allergenic Foods in Breast-Fed Infants

Michael R. Perkin, Kirsty Logan, Anna Tseng, Bunmi Raji, Salma Ayis et al. (12 authors)

New England Journal of Medicine2016-03-04847 citations

10.1056/nejmoa1514210

Interventions

The intervention arm consists of the dietetic controlled introduction of allergenic foods from three months of age. Baby rice mixed with breast milk or water will be commenced first, followed by cow's

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Pregnant mothers attending their 12/20 week ultrasound scans 2. Mothers planning on exclusively breast feeding for at least the first 3 months 3. Informed consent obtained from parent or guardian

Exclusion criteria

Exclusion criteria: 1. Significant antenatal anomaly at 20 week ultrasound scan 2. Multiple pregnancy 3. Significant congenital disease (enteropathy, congenital heart disease, renal disease) 4. Premature delivery (less than 37 completed weeks gestation) 5. Parents not planning on breast feeding exclusively for at least the first 3 months 6. Parents planning on moving away from London before their child is three years of age 7. Parents unable to speak and read English 8. Unwillingness or inability to comply with study requirements and procedures 9. Family intend infant to be on a restricted diet (any of the six intervention foods)

Design outcomes

Primary

Measure	Time frame
The period prevalence of IgE mediated food allergy to the six intervention foods between one and three years of age in both arms	—

Secondary

Measure	Time frame
1. Period (one to three years of age) prevalence food outcomes: 1.1. The period prevalence of all IgE mediated food allergy between one and three years of age in both arms 1.2. The period prevalence of all food allergy (IgE and non-IgE mediated) between one and three years of age in both arms 1.3. The period prevalence of sensitisation to food between one and three years of age in both arms 2. Cumulative (by three years of age) prevalence food outcomes: 2.1. The cumulative prevalence of IgE mediated food allergy to the six intervention foods by three years of age. 2.2. The cumulative prevalence of all IgE mediated food allergy by three years of age 2.3. The cumulative prevalence of all food allergy (IgE and non-IgE mediated) by three years of age 2.4. The cumulative prevalence of non-IgE mediated food allergy by three years of age 2.5. The cumulative prevalence of sensitization to the six foods by three years of age 3. Other allergic disease outcomes: 3.1. The point prevalence of eczema at one year and three years of age and cumulative prevalence of eczema by three years of age 3.2. The severity of eczema at one year and three years of age by Severity Scoring of Atopic Dermatitis index (SCORAD) and Nottingham Eczema Severity Score (NESS) 3.3. The prevalence of allergic rhinitis at three years of age 3.4. The prevalence of inhalant allergen sensitisation at one year and at three years of age by skin prick test 3.5. The prevalence of inhalant allergen sensitisation at one year and at three years of age by specific IgE measurement 3.6. The prevalence of the atopic wheeze phenotype at three years of age 4. Composite allergy outcome: 4.1. The prevalence of combined allergic disease (a	—

Measure

Time frame

1. Period (one to three years of age) prevalence food outcomes: 1.1. The period prevalence of all IgE mediated food allergy between one and three years of age in both arms 1.2. The period prevalence of all food allergy (IgE and non-IgE mediated) between one and three years of age in both arms 1.3. The period prevalence of sensitisation to food between one and three years of age in both arms 2. Cumulative (by three years of age) prevalence food outcomes: 2.1. The cumulative prevalence of IgE mediated food allergy to the six intervention foods by three years of age. 2.2. The cumulative prevalence of all IgE mediated food allergy by three years of age 2.3. The cumulative prevalence of all food allergy (IgE and non-IgE mediated) by three years of age 2.4. The cumulative prevalence of non-IgE mediated food allergy by three years of age 2.5. The cumulative prevalence of sensitization to the six foods by three years of age 3. Other allergic disease outcomes: 3.1. The point prevalence of eczema at one year and three years of age and cumulative prevalence of eczema by three years of age 3.2. The severity of eczema at one year and three years of age by Severity Scoring of Atopic Dermatitis index (SCORAD) and Nottingham Eczema Severity Score (NESS) 3.3. The prevalence of allergic rhinitis at three years of age 3.4. The prevalence of inhalant allergen sensitisation at one year and at three years of age by skin prick test 3.5. The prevalence of inhalant allergen sensitisation at one year and at three years of age by specific IgE measurement 3.6. The prevalence of the atopic wheeze phenotype at three years of age 4. Composite allergy outcome: 4.1. The prevalence of combined allergic disease (a

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Countries

England, United Kingdom

Outcome results

None listed