Effect of single high-dose or daily low-dose vitamin D on muscle strength in older women

The effects of single high-dose or daily low-dosage oral colecalciferol treatment on vitamin D levels and muscle strength in postmenopausal women

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN14226530

Enrollment

Registered

2018-07-04

Start date

2015-02-15

Completion date

Unknown

Last updated

2018-08-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Effect on muscle strength of vitamin D supplementation Nutritional, Metabolic, Endocrine

Interventions

60 healthy postmenopausal women who had serum vitamin D levels <20 ng/ml (50 nmol/l) were enrolled in the study. Group 1 (n=32) was given daily oral dosages of 800 IU vitamin D3, and group 2 (n=28) wa

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Healthy 2. Postmenopausal 3. Aged 50-68 years 4. Vitamin D level <20 ng/ml (50 nmol/l)

Exclusion criteria

Exclusion criteria: 1. Individuals who had granulomatous conditions, thyroid disease, malabsorption syndromes, liver disease, kidney disease, diabetes or postural instability (cerebellar disease, vestibular disease, vitamin B12 deficiency, drugs) 2. Individuals taking anticonvulsants, calcium or vitamin D supplements, barbiturates, or steroids in any form

Design outcomes

Primary

Measure	Time frame
25OH vitamin D levels 3 months after treatment	—

Secondary

Measure	Time frame
Muscle strength 3 months after treatment. Muscle strength tests were performed at 60° using a Biodex system 3 isokinetic dynamometer.	—

Countries

Turkey

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 6, 2026