Nutritional, Metabolic, Endocrine: Adrenal insufficiency Nutritional, Metabolic, Endocrine Adrenal insufficiency
Conditions
Interventions
For the first 4 months each patient would receive either 50 mg of DHEA administered orally or a placebo tablet of identical appearance. Following a washout period of one month the form of therapy woul
Sponsors
Department of Health
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. 20 patients between the age of 20 and 60 years 2. With adrenal insufficiency secondary to panhypopituitarism of varying aetiology 3. Of at least one years duration enrolled from outpatient clinics of City General Hospital 4. They would be adequately replaced with regards to corticosteroid, thyroxine and sex steroid deficiency with unchanged replacement dose over the preceding 3 months 5. None of the patients would receive growth hormone replacement therapy 6. Patients with significant co-morbidity, those with hormone dependent conditions like breast cancer, pregnant women are excluded 7. Written consent would be obtained from all patients
Exclusion criteria
Exclusion criteria: Not provided at time of registration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Body mass index 2. Blood pressure (BP) 3. Quality of life (QoL) assessment 4. Hormone, Biochemical and Endothelial markers (detail give above) 5. Insulin tolerance test 6. Ultrasonographic assessment of endothelial function by checking carotid intima-media thickness 7. Flow mediated dilatation of the brachial artery | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed