Specialty: Dermatology, Primary sub-specialty: Dermatology
Conditions
Interventions
Interventional study:
Participants are randomised to one of two groups (active or control) with a 6:1 allocation using a computer-generated randomisation sequence.
Act
Sponsors
University of Manchester
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Healthy, ambulant, male and female adults aged 65-84 years 2. White Caucasian 3. Willing and capable of participating to the extent and degree required by the protocol
Exclusion criteria
Exclusion criteria: 1. Taking medication influencing vitamin D, or that is bone-active or photoactive 2. History of sunbathing/sunbed use within 3 months 3. History of skin cancer or photosensitivity 4. Taking any vitamin D, fish oil or calcium supplements (intervention study only)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum 25-hydroxyvitamin D concentration measured by liquid chromatography/tandem mass-spectrometry at baseline, 1, 2, 3, 4, 5 and 6 weeks (intervention study) and in September and January (observation study). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Serum parathyroid hormone measured at baseline and week 6 (intervention) and in September and January (observation) 2. Bone turnover markers measured at baseline and week 6 (intervention) and in September and January (observation) 3. Dietary vitamin D intake assessed thorough diet logs at baseline and week 6 (intervention) and in September and January (observation) 4. Sun exposure measured by dosimeter badges and diaries in September and January (observation only) | — |
Countries
United Kingdom
Outcome results
None listed