A comparison between different strategies to handle anticoagulation during cardiac surgery

Heparin titration vs standard dosing - effects on postoperative hemostasis: a prospective randomized study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN14201041

Enrollment

Registered

2015-01-14

Start date

2011-10-25

Completion date

Unknown

Last updated

2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Study anticoagulation strategies during cardiopulmonary bypass. Circulatory System

Interventions

1. Intervention group: HEPCON Haemostasis Management System Plus device (Medtronic Inc, Minneapolis, Minnesota) was used, according to manufacturer’s recommendations. After estimating the patients’ bl

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients undergoing elective coronary artery bypass grafting surgery or single valve repair/replacement on cardiopulmonary bypass 2. >18 years old

Exclusion criteria

Exclusion criteria: 1. Acute operation 2. Known bleeding disorder, liver or kidney disease, 3. Previous stroke 4. Treatment with a P2Y12 receptor antagonist <5 days before surgery

Design outcomes

Primary

Measure	Time frame
Endogenous thrombin potential in plasma 2 hours after surgery as assessed by calibrated automated thrombogram.	—

Secondary

Measure	Time frame
1. Total heparin and protamine doses during the operation 2. Whole blood clot formation as measured with thromboelastometry 10 min, 2h and 4h after the operation 3. Hemostatic analyses (aPTT, PT, anti-thrombin, fibrinogen, platelet count) 10 min, 2h and 4h after the operation 4. Postoperative bleeding volume the first 12 h, Red blood cell transfusion during hospital stay	—

Countries

Sweden

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 4, 2026