Obstructive jaundice Digestive System Other diseases of biliary tract
Conditions
Interventions
Two treatment groups were created according to whether patients received dopamine at 3 mg/Kg/min or not, associated with 3000 ml of saline solution for 48 hours before biliary drainage in addition to
Sponsors
Reina Sofia University Hospital (Spain)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Malignant OJ with serum bilirubin higher than 6 mg/dl 2. Ultrasound evidence of extrahepatic and intrahepatic bile duct dilation (more than 8 mm and 4 mm respectively) 3. Feasibility of internal endoscopic biliary drainage 4. Aged 35 to 76 years, either sex
Exclusion criteria
Exclusion criteria: 1. Cholangitis 2. Acute pancreatitis 3. Heart disease 4. Arterial hypertension 5. Chronic lung disease 6. Use of diuretics 7. Chronic renal failure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Renal function (CrCl), assessed at admission, before drainage, as well as 24 hours and 72 hours after biliary drainage. | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessed at admission, before drainage, as well as 24 hours and 72 hours after biliary drainage: 1. Extracellular water (ECW) volume 2. Serum leves of aldosterone, renin, atrial natriuretic peptide (ANP), antidiuretic hormone (ADH), endothelin-1 (ET-1) 3. Urine prostaglandin E2 (PgE2) | — |
Countries
Spain
Outcome results
None listed