Primary spontaneous pneumothorax Respiratory Pneumothorax
Conditions
Interventions
Administration of inhaled fluorescein at Thoracic Surgery to highlight areas of lung abnormalities.
During surgery patients will be asked to breathe in Fluorescein to show up any abno
Sponsors
University of Oxford
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patient undergoing Video-assisted Thoracoscopic Surgery (VATS) for pneumothorax recurrence prevention, or ongoing air leak (pneumothorax group) OR Thoracic surgery for another indication, for example, early-stage lung cancer or metastasis resection (control group). 2. Male or female aged between 16 and 55 years (inclusive)
Exclusion criteria
Exclusion criteria: 1. Inability to consent or comply with the trial requirements 2. Patients in the control group should not have demonstrable emphysema (on CT scanning) and should not have experienced a spontaneous pneumothorax in the past 3. Allergy to fluorescein 4. Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk because of participation in the study, or may influence the result of the trial, or the participant’s ability to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Descriptive histological findings in lung areas under investigation, measured by the researchers | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Lung genomic analysis measured using mRNA sequencing 2. Autofluorescence measured using digital image analysis software 3. Degree of lung inhomogeneity measured using laser gas analyser (bespoke project with University of Oxford Department of Physiology) 4. Peripheral blood genomic analysis measured using mRNA sequencing | — |
Countries
England, United Kingdom
Outcome results
None listed