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Development of a bloodtest for uterine sarcoma monitoring

Development of a blOOdtest for uteRine Sarcoma – Monitoring (DOORS-M)

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN14174468
Enrollment
50
Registered
2025-06-04
Start date
2025-07-01
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Uterine sarcoma Cancer

Interventions

All participants will be asked questions about their demographics, medical and family history, and any symptoms. Additional information will be taken from their medical records, including information

Sponsors

University of Leicester
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Uterine sarcoma 2. Aged 18 years or older 3. Female

Exclusion criteria

Exclusion criteria: 1. Male 2. Under 18 years 3. Not previously undergone treatment for a uterine sarcoma

Design outcomes

Primary

MeasureTime frame
1. Body Mass Index (BMI) is measured using height and weight recorded with a stadiometer and calibrated scale at baseline (visit 1) 2. Uterine sarcoma diagnostic and treatment data are measured using clinical records review at baseline (visit 1) 3. Medical and family history is measured using patient interview and clinical records review at baseline (visit 1) 4. Symptom burden is measured using a symptom checklist questionnaire at baseline (visit 1) and approximately every 3 months 5. Circulating tumor DNA (ctDNA) presence is measured using a personalized, tumor-informed ctDNA assay (e.g. Signatera) from blood samples at baseline (visit 1) and approximately every 3 months

Secondary

MeasureTime frame
Patient experience of diagnosis, treatment, follow-up, and views on prognostic blood testing is measured using a semi-structured qualitative interview at any time following recruitment

Countries

England, United Kingdom

Contacts

Public ContactEsther Moss
leicestergcrg@le.ac.uk-

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 14, 2026