Malocclusion Oral Health Malocclusion
Conditions
Interventions
The selected subjects will be randomly allocated into two groups (random number list software generated) accordingly to the following treatment protocol:
Group 1: Fixed Appliance grou
Sponsors
University of Torino (Italy)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Dentoskeletal Class I malocclusion (Witts appraisal) 2. Mild crowding (mean crowding 6 mm) 3. Permanent dentition 4. Vertebral maturation as assessed on lateral cephalograms more advanced than CS4 (postpubertal)
Exclusion criteria
Exclusion criteria: 1. Smokers 2. Have gingivitis 3. Have probing pocket depths =4 mm 4. Have loss of clinical attachment =2 mm in the selected or adjacent teeth 5. Had taken anti-inflammatory or antibiotic medications within the previous 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cytokine concentration will be determined from GCF samples using titration and centrifugation at baseline, 1 hour, 7 days and 21 days. | — |
Secondary
| Measure | Time frame |
|---|---|
| Identification of the most biologically efficient technique among fixed appliance and clear aligners by analysing concentrations of Interleukin 1-beta, TGF-beta, RANKL, OPG and OPN in GCF at baseline, 1 hour, 7 days and 21 days. | — |
Countries
Italy
Contacts
Public ContactAndrea Deregibus
Outcome results
None listed