Hypertension Circulatory System
Conditions
Interventions
Simple randomisation using SPSS Software to either:
Index test: immediate pressor response to oral salt (IPROS):
After an 8-hour overnight fast, IPROS data will be collected. Briefly, blood pressure
Sponsors
Lake Lucerne Institute (LLUI)
Eligibility
Sex/Gender
All
Age
21 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Aged 21–50 years, the cut off at age 50 years is related to the association of increased age with salt sensitivity and arterial wall thickening. 2. Participants must have been residing in Europe for more than one year. This cutoff is selected to account for the acculturation effect. 3. Both male and female participants will be recruited, sex will be used as a covariate in all following analysis. Sex is known to influence blood pressure, but difference in the prevalence of salt sensitive blood pressure are unknown. Although sex comparison is not an aim of this study, sex differences will be taken into consideration. 4. All participants are required to be able to give informed consent as documented by signature. 5. Participants in Switzerland must be able to understand English, German or Italian, participants in the UK must be able to understand English, and participants in Italy must be able to understand English or Italian.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating 2. Diagnosed hypertension or other conditions known to influence blood pressure (e.g. advanced chronic kidney disease, heart failure, secondary hypertension). 3. Participants must not be taking any blood pressure regulating medication. Blood pressure medication will impact response to dietary salt. 4. Participants must not have a resting blood pressure of higher than 130/80 mmHg.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the receiver operating characteristic curve (AUROC) value of IPROS compared to the reference methodology measured using the salt sensitivity classifications (mean arterial pressure change or percentage change between diets) at 255 participants completing the entire protocol | — |
Secondary
| Measure | Time frame |
|---|---|
| The influence of salt taste profile on salt taste sensitivity measured using recognition and detection threshold and liking and intensity, at 255 participants completing the IPROS protocol and after the entire study protocol;The association of IPROS with short-term blood pressure-related risk factors of cardiovascular disease (CVD) measured using mean arterial pressure and blood pressure at 55 participants completing the IPROS protocol and after the entire study protocol;The association of IPROS and salt sensitivity with genetic variations measured using genetic analysis at 255 participants completing the IPROS protocol and after the entire study protocol | — |
Countries
England, Italy, Switzerland, United Kingdom
Contacts
Public ContactCatherine Graham
Outcome results
None listed