Pre-ablation endometrial preparation: a comparison between GnRH agonist leuporelin and GnRH antagonist Cetrorelix. A Randomised Controlled Trial.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN14156709

Enrollment

100

Registered

2005-09-30

Start date

2003-10-31

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgery: Transcervical Endometrial Resection (TCRE) Surgery Transcervical Endometrial Resection (TCRE)

Interventions

Comparison between GnRH agonist leuporelin and GnRH antagonist Cetrorelix.

Eligibility

Inclusion criteria

Inclusion criteria: 100 eligible women will be identified from those already on the waiting list for Transcervical Endometrial Resection (TCRE). They will be suitable candidates for the procedure and those with submucous fibroid will not be excluded.

Exclusion criteria

Exclusion criteria: 1. Women on hormonal medications within last 3 months 2. Uterine size more than 12 weeks 3. Previous TCRE

Design outcomes

Primary

Measure	Time frame
1. Endometrial thickness as measured on trans-vaginal ultrasound (sagittal plane) on the day of operation 2. Histological assessment of "endometrial chippings" 3. Comparison of side effect profile 4. Operative difficulties 5. Overall patient satisfaction	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026