Non-tuberculosis (TB) bacteria in patients with TB in Kampala, Uganda

Insight into the role of the microbiome in pulmonary tuberculosis in Kampala, Uganda

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN14141535

Enrollment

800

Registered

2022-03-17

Start date

2021-10-01

Completion date

Unknown

Last updated

2022-03-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Investigation of the microbiome of patients with tuberculosis Not Applicable

Interventions

In the proposed project, we will investigate sputum, stool and blood samples from a total of 800 participants at baseline (day 0 before administering therapy), as well as months 2, 5, 12, 18 and 24 fo

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: New adult TB patients 18 years and older

Exclusion criteria

Exclusion criteria: 1. Previously treated TB patients 2. Children

Design outcomes

Primary

Measure	Time frame
Microbiome composition and diversity measured from stool sample using the alpha and beta diversity indices in the 'R' statistical package at baseline (time 0) and at 2, 5, 12, 18, and 24 months	—

Secondary

Measure	Time frame
Cytokine profiles relative to the microbiome composition and diversity measured using serum/plasma, blood, stool and sputum samples using the ELISA assay at baseline (time 0)	—

Countries

Uganda

Contacts

Public ContactGeraldine Nalwadda

geraldine.nalwadda@mak.ac.ug+256414541830

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026