Music combined with touch therapy to decrease pain response in preterm infants

Effect of music combined with touch therapy on pain response and level of beta-endorphine and cortisol in late preterm infants

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN14131492

Enrollment

Registered

2016-07-29

Start date

2011-06-01

Completion date

Unknown

Last updated

2019-09-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cortisol and ß-endorphin levels in pre-term infants Nutritional, Metabolic, Endocrine Cortisol and ß-endorphin levels in pre-term infants

Interventions

After consent is obtained from parents, infants are randomly assigned to either the experimental or control group using a random numbers table. Participants in both groups undergo a range of painful p

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Admitted within 72 hours after birth 2. Gestational age is less than 37 weeks

Exclusion criteria

Exclusion criteria: 1. Serious birth injuries 2. Serious malformations (especially in oral cavity or external ear deformity) 3. Significant parenchyma brain injury (IVH grade IV, or PVL) 4. Had received analgesics or sedatives within 72 h of the assessment 5. Failed hearing screening.

Design outcomes

Primary

Measure	Time frame
Pain is measured using the premature infants’ pain profile (PIPP) at baseline and 2 weeks.	—

Secondary

Measure	Time frame
1. Cortisol levels are measured using blood testing at baseline and 2 weeks 2. Beta-endorphin levels are measured using blood testing at baseline and 2 weeks	—

Countries

China

Contacts

Public ContactJie Qiu

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 27, 2026