Pulmonary hypertension Circulatory System
Conditions
Interventions
All patients deemed necessary will undergo initiation of targeted pulmonary hypertension therapy. They will be followed up at baseline, 3 and 6 months with quality of life scores, monitoring their act
Sponsors
Newcastle upon Tyne Hospitals NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients’ aged greater than 18 years 2. Underlying diagnosis of pulmonary hypertension confirmed by the National Pulmonary Hypertension Service(Newcastle) 3. World Health Organization (WHO) functional Class II to IV
Exclusion criteria
Exclusion criteria: 1. Patients who are unable to provide informed consent 2. Patients with recent syncope 3. Patients with known skeletal and muscle abnormalities 4. Patients with ischaemic heart disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change in peak oxygen consumption (VO2) with PH specific treatment. Measured at baseline, 3 and 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Change in habitual physical activity levels with treatment. 2. Change in cardiac output and peripheral muscle oxygen extraction during exercise with PH-specific treatment. Measured at baseline, 3 and 6 months | — |
Countries
United Kingdom
Outcome results
None listed