Eosinophilic oesophagitis (EoE) Digestive System
Conditions
Interventions
Patients will be asked to undergo a capsule sponge test prior to a standard endoscopy with biopsy
Sponsors
Cyted Ltd
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Over 18 years old with a histologically confirmed diagnosis of EoE 2. Male or Female 3. Newly diagnosed patients with EoE or known existing non-stenotic EoE patients who are on maintenance treatments (i.e., orodispersible budesonide, PPI, biologics, or dietary therapy) and monitoring 4. Patients currently enrolled in the CoSIE study (IRAS 314770) may be retrospectively included with consent
Exclusion criteria
Exclusion criteria: 1. Age =3
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Eosinophil count in biopsy vs sponge pathology (number of eosinophils per high power field - standard measures in diagnosis) at time of procedure and for the sub-group at follow-up 8-12 weeks later 2. Biomarker quantification using ELISA assays for selected biomarkers at time of procedure and for the sub-group at follow-up 8-12 weeks later 3. Severity of symptoms measured using the Dysphagia Symptom Questionnaire (DSQ) at time of procedure and for the sub-group at follow-up 8-12 weeks later | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient satisfaction measured using survey at time of procedure and for the sub-group at follow-up 8-12 weeks later | — |
Countries
England, United Kingdom
Contacts
Public ContactSamantha Roberts
Outcome results
None listed