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Autologous platelet-derived product for palatal wound healing after plastic surgery in comparison with standard surgical gelatin sponges in order to improve post-surgery experience

Clinical assessment of A-PRF application on the healing process of palatal wound after connective tissue graft harvest: a randomized clinical trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN14065920
Enrollment
52
Registered
2020-02-12
Start date
2020-02-03
Completion date
Unknown
Last updated
2020-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Palatal wound after connective tissue graft harvest Oral Health

Interventions

Patients were randomly assigned in a 1:1 ratio to the PRF group or control group. A random allocation sequence was performed by using a randomization program (http://www. randomizer.org). Although the

Sponsors

Egas Moniz - Cooperativa de Ensino Superior
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients ranging from 18 to 45 years of age 2. Need connective tissue for tunnel operation or coronally flap operation 3. Non-smoking 4. Good oral hygiene 5. No gag reflex 6. No periodontal surgery before at operation site

Exclusion criteria

Exclusion criteria: 1. Systemic disorders (immunologic diseases, uncontrolled diabetes mellitus, ongoing chemotherapy or radiotherapy) 2. Pregnancy/lactation/menstruation 3. Chronic use of anti-inflammatory or analgesic 4. Inability or unwillingness to provide informed consent

Design outcomes

Primary

MeasureTime frame
Pain assessed using the Visual Analogue Scale at baseline and for the following 30 days after surgery

Secondary

MeasureTime frame
1. Edema visually measured at 7, 14 and 30 days after surgery 2. Analgesic consumption measured using a personal diary at baseline and for the following 30 days after surgery 3. Healing process measured using early healing index at 7, 14 and 30 days after surgery. 4. Connective tissue graft volume and PRF volumes measured using a periodontal probe during surgery

Countries

Portugal

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026