How to recover from total knee arthroplasty with less pain

Effects of cold irrigation on early results after total knee arthroplasty (TKA) – A randomized, double-blind, controlled study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN14054997

Enrollment

420

Registered

2015-08-25

Start date

2014-12-21

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Degenerative knee joint osteoarthritis Musculoskeletal Diseases Degenerative knee joint osteoarthritis

Interventions

Control Group: Patients are intraoperatively administered with continuous irrigation of 4000ml saline of normal temperature during the whole total knee arthroplasty (TKA) procedure. Normal irrigation

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing primary, unilateral total knee arthroplasty (TKA) due to degenerative knee joint osteoarthritis.

Exclusion criteria

Exclusion criteria: 1. Severe hypertension and cardiovascular diseases 2. Allergy to epinephrine and cold stimulation

Design outcomes

Primary

Measure	Time frame
Pain at rest is measured by a 100 mm visual analogue scale (VAS), at 24, 48 and 72 hours after surgery.	—

Secondary

Measure	Time frame
1. Analgesic consumption is measured during hospitalisation. This depended on total doses of morphine used by PCA treatment, weak opioid analgesic and NSAID in every 12 hours 2. Drainage output was recorded and compared following extracting the drainage tube after 24 hours. Drainage output reflected dominant blood loss partly. Finally analyzed drainage output in this study resulted from deducting 50ml irrigation solution infused before surgery from recorded total output 3. Hemoglobin levels are measured 72 hours after surgery to find if levels have decreased 4. Knee joint girth as a reflection of swelling level and local inflammation was measured above 1 cm proximal to the upper border of the patella before operation, and at 48 and 96 hours after operation	—

Measure

Time frame

1. Analgesic consumption is measured during hospitalisation. This depended on total doses of morphine used by PCA treatment, weak opioid analgesic and NSAID in every 12 hours 2. Drainage output was recorded and compared following extracting the drainage tube after 24 hours. Drainage output reflected dominant blood loss partly. Finally analyzed drainage output in this study resulted from deducting 50ml irrigation solution infused before surgery from recorded total output 3. Hemoglobin levels are measured 72 hours after surgery to find if levels have decreased 4. Knee joint girth as a reflection of swelling level and local inflammation was measured above 1 cm proximal to the upper border of the patella before operation, and at 48 and 96 hours after operation

—

Countries

China

Contacts

Public ContactLong Gong

Gonglong301@163.com+8618618151631

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026