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Effectiveness of silver fluoride agents to arrest caries in children

Detection of the cariostatic efficacy of silver diamine fluoride and nano-silver fluoride using reveal fluorescence dental loupes in children

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN14037606
Enrollment
100
Registered
2022-07-11
Start date
2021-12-15
Completion date
Unknown
Last updated
2022-08-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Treatment of cavitated carious lesions in primary molars in children Oral Health

Interventions

Eligible teeth with cavitated carious lesion in preschool children will be randomly divided into 2 groups: Silver diamine fluoride, arm 1 Nano-Silver Fluoride biologically synthesized, arm 2 The affec

Sponsors

Damascus University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Have not received antibiotic therapy in the past month before sampling. 2. Good oral hygiene. 3. Co-operative patients approving the trial. 4. Untreated cavitated active caries lesion with dentin exposed based on the ICDAS II (Code 5: dentin cavity easily visible with the naked eye where the surface of cavity feels soft or leathery on gentle probing ) 5. Absence of spontaneous pain; negative sensitivity to percussion

Exclusion criteria

Exclusion criteria: 1. Children weight less than 15 kg. 2. known sensitivity to silver or other heavy-metal ions 3. presence of any gingival or perioral ulceration or stomatitis or presence of a tooth abscess.

Design outcomes

Primary

MeasureTime frame
Caries Arrest will be measured using Reveal Fluorescence Dental loupes at (T0) Baseline and re-evaluated at (T1) : 3 weeks after applying topical agents. and (T2): 3 months after applying topical agents

Secondary

MeasureTime frame
Patient discomfort will be assessed using Wong-Baker Faces scale, It will be assessed immediately after the sequence of treatments have been performed.

Countries

Syria

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026