Radical cure of vivax malaria

Open label comparison of Chloroquine (CQ) alone versus CQ plus 5 days unobserved Primaquine or CQ plus 14 days unobserved primaquine

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN14027467

Enrollment

150

Registered

2011-11-16

Start date

2003-04-01

Completion date

Unknown

Last updated

2017-06-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vivax malaria Infections and Infestations Plasmodium vivax malaria

Interventions

1. Chloroquine (25mg base/kg total) only

10mg/kg on day 1, 10mg/kg on day 2 then 5mg/kg on day 3 2. Chloroquine (25mg base/kg total as above) followed by primaquine 0.25mg base/kg/day for 5 days-total dose 1.25mg base/kg (75mg in an adult) 3

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age > 3 years 2. Fully informed consent to long follow-up 3. Acute uncomplicated vivax malaria 4. Not pregnant

Exclusion criteria

Exclusion criteria: 1. <3 years 2. Pregnancy 3. Severe disease

Design outcomes

Primary

Measure	Time frame
Relapse rate	—

Secondary

Measure	Time frame
Adverse effects	—

Countries

India

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 26, 2026