Perceptual learning in enhanced amblyopia treatment

Perceptual Learning in Enhanced Amblyopia Treatment: an exploratory randomised controlled trial in the treatment of amblyopia

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN14022536

Enrollment

Registered

2014-11-21

Start date

2015-08-31

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Amblyopia Eye Diseases

Interventions

Perceptual learning treatment administered using a computer and eMagin gaming goggles You will be randomised to one of three treatment groups using an automated telephone service provided by the Robe

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age 5 to 17 years 2. Visual acuity of 0.2 log units or lower in worst eye and/or interocular difference of at least 0.1 log units 3. Presence of anisometropia >1.00 MSE and/or strabismus/microtropia. 4. Not receiving any active conventional amblyopia treatment 5. Participants will all have a refraction, fundus and media check within 6 months prior to enrolment and will wear their up-to-date refractive correction for testing and training. It is important to establish that full spectacle adaptation has occurred.

Exclusion criteria

Exclusion criteria: 1. Stimulus deprivation amblyopia 2. Presence of other known ophthalmic defect (bar refractive error) 3. Receiving active conventional amblyopia treatment 4. Cortical visual impairment 5. Photosensitive epilepsy 6. Physical impairment affecting ability to use mouse/keyboard 7. Previous perceptual learning treatment

Design outcomes

Primary

Measure	Time frame
Proportion of patients with visual acuity improvement of 0.1 log units or better in the amblyopic eye at the end of the training period	—

Secondary

Measure	Time frame
1. Sensory fusion status (assessed with Bagolini glasses) 2. Motor fusion reserves (measured using horizontal prism bar) 3. Stereoacuity (measured using Frisby and/or Preschool Randot Stereotest) 4. Interocular suppression density (measured using Sbisa bar) 5. Angle of strabismus (measured using prism cover test) 6. Severity of perceptual visual distortions (measured using a 5 minute computer game that has been extensively piloted with amblyopic and visually normal children) These are measured at the end of training.	—

Measure

Time frame

1. Sensory fusion status (assessed with Bagolini glasses) 2. Motor fusion reserves (measured using horizontal prism bar) 3. Stereoacuity (measured using Frisby and/or Preschool Randot Stereotest) 4. Interocular suppression density (measured using Sbisa bar) 5. Angle of strabismus (measured using prism cover test) 6. Severity of perceptual visual distortions (measured using a 5 minute computer game that has been extensively piloted with amblyopic and visually normal children) These are measured at the end of training.

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026