The effect of post-intensive care unit nutrition support on recovery after critical illness. Nutritional, Metabolic, Endocrine
Conditions
Interventions
Patients expected to be discharged from ICU within 72 hours are screened for inclusion. After obtaining informed consent, study subjects are randomised to one of the two treatment arms:
- Interventi
Sponsors
Karolinska University Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. 18 years or older 2. ICU length of stay >72 hours 3. Received invasive mechanical ventilation for 48 hours or more 4. Received enteral or parenteral nutrition during ICU stay 5. Discharged or expected to be discharged alive from ICU within 72 hours of enrollment
Exclusion criteria
Exclusion criteria: 1. Inability to provide informed consent 2. > 72 hours between ICU discharge and enrollment 3. Inherited or acquired disorders of amino acid metabolism where high protein intake is contraindicated 4. Central nervous system injury (prior to or during hospitalisation) with impaired lower limb motor function expected to interfere with outcome assessment 5. Pre-existing cognitive impairment or language barrier expected to prevent outcome assessment or informed consent 6. Primary neuromuscular disease (e.g. myasthenia gravis, Guillanne Barré, multiple sclerosis with impaired lower limb motor function) 7. Severe lower limb arterial insufficiency expected to prevent outcome assessment 8. Lower extremity impairments (e.g. amputation, fractures, arthritis) preventing outcome assessment 9. Morbid obesity where subcutaneous adipose tissue prevents visualisation on muscle ultrasound 10. Expected dealth during hospitalisation or limitations in treatment to best supportive care 11. CAM-ICU positive on screening (patient can be screened again if delirium resolves) 12. Milk protein allergy 13. Unable to walk independently prior to acute illness resulting in ICU admission (walking aid permitted) 14. Renal insufficiency with eGFR < 45ml/min/1.73m2 15. Decompensated cirrhosis with hepatic encephalopathy 16. Treating physician at receiving ward does not consider randomisation to treatment targets to be in the best interest of the patient 17. Acute or chronic macronutrient malabsorption (i.e. high output ileostomy, intestinal failure) where the physician responsible for the patient's short or long-term care does not consider randomisation to treatment targets to be in the best interest of the patient 18. Pregnancy
Countries
Sweden
Contacts
Public ContactRebecca Lindström
Outcome results
None listed