Obesity hypoventilation syndrome Respiratory Obesity hypoventilation syndrome
Conditions
Interventions
Participants undergoing treatment for obesity hypoventilation syndrome (OHS) undergo a systematic pre-established switch from using non invasive ventilation (NIV) to using a continuous positive airway
Sponsors
Alain Palot
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. 18 years old or older 2. Suffering from obesity hypoventilation syndrome (OHS) defined as an association of obesity (BMI = 30 kg/m²) and daytime hypercapnia (paCO2 > 45 mm Hg)) 3. Patients who had been undergoing noninvasive ventilation (NIV) for more than 2 months 4. Clinically stable for at least 4 weeks before enrollment in the study (no hospitalization or emergency admission)
Exclusion criteria
Exclusion criteria: 1. Hypercapnia secondary to other causes (obstructive pulmonary diseases (FEV1/FVC < 70), interstitial lung diseases, neuromuscular or chest wall diseases, severe hypothyroidism or congenital central hypoventilation syndrome) 2. Patients unable to give informed consent to data collection and analysis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of sleep apnea is measured using the Apnea-Hypopnea index at baseline and 1 month after starting of CPAP. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Oxygen saturation and transcutaneous measurement of pCO2 are measured using daytime arterial blood gas and nocturnal alveolar gas exchange at baseline and 1 month after starting of CPAP 2. Sleepiness is measured using the Epworth Sleepiness Scale (EPS) at baseline and 1 month after starting of CPAP 3. Quality of sleep is measured using the Pittsburgh Sleep Quality Index (PSQI) at baseline and 1 month after starting of CPAP 4. Quality of life is measured using Severe Respiratory Insufficiency questionnaire (SRI) at baseline and 1 month after starting of CPAP | — |
Countries
France
Outcome results
None listed