Does session duration affect lung function during exercise in the cold?

Influence of exercise duration on respiratory responses to exercise in sub-zero conditions

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN13977758

Enrollment

Registered

2022-02-01

Start date

2021-01-01

Completion date

Unknown

Last updated

2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory responses to exercise in cold in healthy individuals

Interventions

Participants performed a preliminary test to determine their maximal oxygen uptake and running speed to elicit 60% maximal oxygen uptake, followed by two experimental trials. During the trials, partic

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age 18-45 years 2. Undertaking regular endurance training, including a prolonged session (>90 min) at least once every 3 weeks

Exclusion criteria

Exclusion criteria: 1. Never have trained/competed at elite level in an endurance sport 2. Smoker 3. History of chronic asthma, current asthma diagnosis and/or cardiovascular or chronic inflammatory disease 4. Respiratory symptoms 48h prior to each trial 5. (Female participants): not pregnant or breastfeeding, pre-menopausal

Design outcomes

Primary

Measure	Time frame
1. Lung function (spirometry: FEV1, FVC, FEV1/FVC; impulse oscillometry: R5, R20 and X5); pre, 12 and 50 min post-exercise. 2. Lower airway (4-item, YES/NO) and cold-induced symptoms (9 item questionnaire, Borg CRE scale): pre, post, 20 min and 24h post-exercise. 3. White cell counts using blood test (pre, 10 min post and 65 min post-exercise) 4. Blood biomarkers of airway epithelial damage (serum CC-16) using blood test (pre, 10 min post and 65 min post-exercise)	—

Measure

Time frame

1. Lung function (spirometry: FEV1, FVC, FEV1/FVC; impulse oscillometry: R5, R20 and X5); pre, 12 and 50 min post-exercise. 2. Lower airway (4-item, YES/NO) and cold-induced symptoms (9 item questionnaire, Borg CRE scale): pre, post, 20 min and 24h post-exercise. 3. White cell counts using blood test (pre, 10 min post and 65 min post-exercise) 4. Blood biomarkers of airway epithelial damage (serum CC-16) using blood test (pre, 10 min post and 65 min post-exercise)

—

Secondary

Measure	Time frame
1. Atopic or non-atopic determined using AQUA© (cut off score =5) at the preliminary visit 2. Exhaled particle count and analysis (exploratory analysis; collected pre and 20-30 min post-exercise; particle counts and mass as well as possible mass spectrometry analysis (‘omics’)) 3. Other biomarkers from biobank serum samples (HSP70; Eotaxin, Periostin, 8-isoprostane; or other immune/inflammatory markers; pre, 10 min post and 65 min post-exercise)	—

Measure

Time frame

1. Atopic or non-atopic determined using AQUA© (cut off score =5) at the preliminary visit 2. Exhaled particle count and analysis (exploratory analysis; collected pre and 20-30 min post-exercise; particle counts and mass as well as possible mass spectrometry analysis (‘omics’)) 3. Other biomarkers from biobank serum samples (HSP70; Eotaxin, Periostin, 8-isoprostane; or other immune/inflammatory markers; pre, 10 min post and 65 min post-exercise)

—

Countries

Sweden

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 12, 2026