Refractory and unexplained chronic cough Respiratory
Conditions
Interventions
Subjects will be recruited from the specialist Cough Clinic and undergo the following procedures:
Baseline:
1. Cough visual analogue scale (VAS)
2. Numerical (Likert) cough severity score
3. Cough-re
Sponsors
Manchester University NHS Foundation Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adults over the age of 18 years 2. Referred to the tertiary chronic cough clinic 3. Non-smokers or ex-smokers <20 pack years and greater than 6 months of abstinence 4. Persistent cough of at least 8 weeks duration
Exclusion criteria
Exclusion criteria: 1. Currently taking angiotensin-converting enzyme (ACE) inhibitors 2. Recent history of upper or lower respiratory tract infection or significant change of pulmonary status within 4 weeks of enrolment 3. Current smoker or smoking history >20 pack years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Characteristics and severity of cough measured using the ToPiC questionnaire score before treatment (Day 1) and after completion of investigation and treatment (3-6 months) after enrolment | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured before treatment (Day 1) and after completion of investigation and treatment (3-6 months) after enrolment: 1. 24-hour cough frequency measured using VitaloJAK 2. Cough-related quality of life measured using the Leicester Cough Questionnaire [LCQ]) 3. Patient-reported cough severity measured using cough visual analogue scale (VAS) | — |
Countries
England, United Kingdom
Outcome results
None listed