Survival, quality of life and health resource use following hospitalisation for chronic obstructive pulmonary disease (COPD) exacerbations

Survival, quality of life and health resource use following hospitalisation for chronic obstructive pulmonary disease (COPD) exacerbations: a longitudinal, single-centre, observational study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN13946813

Enrollment

600

Registered

2008-09-12

Start date

2008-12-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute exacerbations of chronic obstructive pulmonary disease (COPD) Respiratory Other chronic obstructive pulmonary disease

Interventions

All patients admitted who satisfy the above inclusion and exclusion criteria will be invited to participate in the study. We intend to recruit 150 patients requiring non-invasive ventilation (NIV) and

age, gender, body mass index (BMI), frequency of exacerbations, frequency of admissions, previous spirometry, smoking history, exercise tolerance, ability to perform ADLs, performance status, previous

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Both males and females, age over 40 years 2. Current or former smoker with a smoking history greater than 10 pack years 3. Diagnosis of chronic obstructive pulmonary disease, supported by spirometry 4. Infective exacerbation or pneumonia

Exclusion criteria

Exclusion criteria: 1. Malignancy or other serious life-threatening co-morbidity 2. Severe cognitive impairment/dementia 3. Domiciliary ventilatory support prior to admission

Design outcomes

Primary

Measure	Time frame
1. In-hospital and 6 month survival 2. Univariate and independent predictors of in-hospital and 6 month survival	—

Secondary

Measure	Time frame
1. Duration quality of life maintained above baseline 2. Mean improvement in quality of life, assessed in 150 patients not requiring NIV and 150 patients requiring NIV at discharge, 6 weeks, 3 months and then 3 monthly intervals for 1 year. This will be assessed by the following: St. Georges Respiratory Questionnaire, 36-item Short Form health survey (SF-36), Hospital Anxiety and Depression Score, Nottingham Extended Activities of Daily Living Scale 3. Discharge destination 4. Frequency of exacerbations 5. Frequency of hospital admissions and length of stay 6. Provision of palliative care services	—

Measure

Time frame

1. Duration quality of life maintained above baseline 2. Mean improvement in quality of life, assessed in 150 patients not requiring NIV and 150 patients requiring NIV at discharge, 6 weeks, 3 months and then 3 monthly intervals for 1 year. This will be assessed by the following: St. Georges Respiratory Questionnaire, 36-item Short Form health survey (SF-36), Hospital Anxiety and Depression Score, Nottingham Extended Activities of Daily Living Scale 3. Discharge destination 4. Frequency of exacerbations 5. Frequency of hospital admissions and length of stay 6. Provision of palliative care services

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026