Acute respiratory infections and gastroenteritis Infections and Infestations
Conditions
Interventions
This is a longitudinal observational study. At recruitment, participants will undergo a face-to-face interview carried out by study staff
data from this interview will be updated in a follow-up interview every 3 months. After recruitment, and every day, for 18 months, participants will be surveyed about their ability to carry out their
Sponsors
Prisma
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Living in a randomly selected household in the study setting 2. Provision of informed written consent
Exclusion criteria
Exclusion criteria: 1. Individuals expected to move out of the selected address during the study period 2. Adults without legal capacity 3. Illiteracy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| From individuals identified to have a new episode of acute respiratory infections (ARI) and/or acute gastroenteritis (AGE) from the daily symptoms surveillance, we will report the: 1. The frequency and incidence rate of specific infections measured using the rapid point-of-care test or multiplex PCR-based assay of the sample collected within 24 hours of identifying a new ARI/AGE episode 2. The frequency of symptoms by specific pathogens measured using the rapid point-of-care tests or multiplex PCR-based assays of the sample collected within 24 hours of identifying a new ARI/AGE episode 3. Genetic diversity of SARS-CoV-2, RSV, influenza and norovirus measured using sequencing of samples collected within 24 hours of identifying a new ARI/AGE episode | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Measure the association between the incidence rate of overall and pathogen-specific ARI and AGE episodes as described in the primary outcome measures with individual/household level factors recorded in a locally validated questionnaire at recruitment and updated every 3 months. 2. Describe the secondary attack rate of ARI and AGE within household contacts of ARI/AGE overall and by pathogen by ARI and AGE episodes as described in the primary outcome measures. 3. Measure and describe the frequency of detection and genetic diversity of ARI and AGE-associated pathogens by multiplex PCR-based assays and metagenomics analysis from wastewater specimens collected weekly from participating communities' wastewater outlets. | — |
Countries
Peru
Contacts
Public ContactSumona;Carlton Datta;Evans
;
Outcome results
None listed