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Reducing antibiotic resistance through adequate use of antibiotics

RESIST: Reducing antibiotic RESISTance through adequate use of antibiotics for acute respiratory tract infections

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN13934505
Enrollment
3000
Registered
2018-12-06
Start date
2017-04-01
Completion date
Unknown
Last updated
2020-10-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute respiratory tract infection Respiratory Acute respiratory tract infection

Interventions

Participating physicians will complete an online training course (CME acknowledged), that focuses on doctor-patient communication, shared decision-making and rational antibiotic therapy among patients

Sponsors

Association of Substitute Health Funds e.V. (vdek e.V.)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients: 1. Aged 1 year or older 2. Health insurance with a substitute health fund 3. Physician consultation visit due to ARTI (upper respiratory infection (URTI) and lower respiratory infection (LRTI)) 4. Otherwise healthy Physicians: 1. General practitioners, pediatricians and otorhinolaryngologists 2. Registration with any participating “Association of Statutory Health Insurance Physicians” located in Bavaria, Baden-Wuerttemberg, Lower Saxony, North Rhine, Westphalia-Lippe, Brandenburg, Mecklenburg-Western Pomerania and Saarland

Exclusion criteria

Exclusion criteria: Data of patients who meet at least one of the following criteria: 1. Underlying chronic diseases, which may affect the immune status in any relevant matter (e.g. chronic obstructive pulmonary diseases, cystic fibrosis, immune deficiency of other causes) 2. Pregnancy 3. Other relevant infectious diseases e.g. urinary tract infections

Design outcomes

Primary

MeasureTime frame
Physicians' overall annual antibiotic prescription rate (regardless of the diagnosis), for all patients insured with a substitute health fund before and after the intervention. This is obtained from routine healthcare data from the "Central Research Institute of Ambulatory Health Care in Germany“ (Zi), assessed using 2016 data (before the intervention), 2017 data and 2018 Q1 data ( available 28/02/2019) and 2018 Q2, Q3 and Q4, and 2019 Q1 data (available 31/12/2019)

Secondary

MeasureTime frame
1. Annual antibiotic prescription rate per practice/physician for all patients insured with one of the substitute health funds diagnosed with ARTI before and after the RESIST intervention 2. Quality of antibiotic prescription practice measured by internationally accredited quality indicators (ESAC-Net indicators) 3. A process evaluation, focusing on the practical feasibility of the RESIST program, assessed using: 3.1. Focus group discussions with physicians participating in RESIST between January and July 2017 3.2. Telephone interviews with patients treated by a participating physician due to ARTI between January and July 2017

Countries

Germany

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 18, 2026