The effect of breakfast fruit meal sequence and physical exercise on glucose level and DPP4 activity among patients with diabetes

Acute effects of breakfast fruits meal sequence and postprandial exercise on blood glucose level and DPP4 activity among type 2 diabetes mellitus patients: a pilot study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN13920339

Enrollment

Registered

2022-05-13

Start date

2017-07-23

Completion date

Unknown

Last updated

2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes mellitus Nutritional, Metabolic, Endocrine

Interventions

Initially, we distributed our research plan to all Health Clinics for Management Program of Chronic Diseases in Surakarta and nearby cities. However, only two Health Clinics at Taksikmadu District, Ka

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Diagnosed with T2DM 2. Aged 45–65 years old 3. Able to ingest fresh fruits

Exclusion criteria

Exclusion criteria: 1. Taking DPP4 inhibitors (sitagliptin, vildagliptin, and similar drugs) 2. Patients with comorbidities such as heart, renal, and hepatic diseases

Design outcomes

Primary

Measure	Time frame
Measured on days 1 and 7: 1. Fasting blood glucose level was measured using the hexokinase method 2. One hour postprandial blood glucose level was measured using the same method 3. Fasting DPP4 activity was determined using a colorimetric assay with a synthetic Gly-Pro-p nitroanilide substrate 4. One hour postprandial DPP4 activity was determined using the same assay with a synthetic Gly-Pro-p nitroanilide substrate	—

Measure

Time frame

Measured on days 1 and 7: 1. Fasting blood glucose level was measured using the hexokinase method 2. One hour postprandial blood glucose level was measured using the same method 3. Fasting DPP4 activity was determined using a colorimetric assay with a synthetic Gly-Pro-p nitroanilide substrate 4. One hour postprandial DPP4 activity was determined using the same assay with a synthetic Gly-Pro-p nitroanilide substrate

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Secondary

Measure	Time frame
1. Basic characteristics including age, gender, marital status, education, job, food allergy, duration of type 2 diabetes illness, and type of oral antidiabetic drugs. These data were collected using open questionnaires consisting of short questions and performed one week before the research commenced. 2. Nutritional Intake (macro- and micronutrients) was collected using a 24-hour food recall questionnaire on days 1 and 7 and converted into daily intake values of macro- and micronutrients using the free nutrisurvey software (https://www.nutrisurvey.de), which has been translated into the Indonesian language	—

Measure

Time frame

1. Basic characteristics including age, gender, marital status, education, job, food allergy, duration of type 2 diabetes illness, and type of oral antidiabetic drugs. These data were collected using open questionnaires consisting of short questions and performed one week before the research commenced. 2. Nutritional Intake (macro- and micronutrients) was collected using a 24-hour food recall questionnaire on days 1 and 7 and converted into daily intake values of macro- and micronutrients using the free nutrisurvey software (https://www.nutrisurvey.de), which has been translated into the Indonesian language

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Countries

Indonesia

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026