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Clinical efficacy of acacia nilotica (Arabic gum) extract on prevention of dry socket after impacted lower third molar surgery: a randomized controlled trial

The efficacy of acacia nilotica extract on the prevention of alveolar osteitis after impacted lower third molar surgery: a randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN13917370
Enrollment
40
Registered
2025-04-22
Start date
2023-10-01
Completion date
Unknown
Last updated
2025-05-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prevention of postoperative complications after extraction of impacted lower third molars Oral Health

Interventions

Method of randomization: Systematic allocation was used (alternate allocation based on the patient’s presence at the dental clinic). Patients with impacted lower third molars with a moderate difficul

Sponsors

King Khalid University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Adult patients (aged 18 years and above) 2. Referred to extract their impacted lower third molars with a moderate difficulty index (scores between 5 and 6) according to the Pederson scale

Exclusion criteria

Exclusion criteria: 1. History of sensitivity to Acacia Nilotica 2. Uncontrolled systemic diseases 3. History of malignancy or irradiation to the site of extraction 4. History of antibiotics, corticosteroids, anticoagulants, and contraceptive drugs use over the past month 5. Smokers 6. Pregnant or breastfeeding mothers 7. Uncontrolled infection at the site of extraction

Design outcomes

Primary

MeasureTime frame
1. Pain measured using a visual analog scale, ranging from 0 (“no pain”) to 10 (“unbearable pain”) at 9 pm for 7 consecutive days 2. Trismus evaluated using a Vernier gauge to measure the interincisal distance between the right upper and lower central incisors at day 1, 3 and 7 post-extraction 3. Extraoral swelling measured with a 3-0 silk suture put between tragus and corner of mouth, following the maximal convexity of the cheek, and measured against a ruler at day 1, 3 and 7 post-extraction 4. Wound healing evaluated by checking wound edges, color of mucosa and wound closure at day 7 post-intervention after suture removal

Secondary

MeasureTime frame
Signs of other postoperative complications, such as postoperative infection and pus discharge

Countries

Saudi Arabia

Contacts

Public ContactMashail Hamid
mhamid@kku.edu.sa+966 (0)555967705

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026