Evaluating the benefits of stocking and heparin in DVT prevention

Conditions

Venous thromboembolism Circulatory System Prevention of venous thromboembolism (VTE) in patients undergoing surgery

Joseph Shalhoub, Rebecca Lawton, Jemma Hudson, Christopher Baker, Andrew W. Bradbury et al. (14 authors)

Health Technology Assessment2020-12-0115 citations

Graduated compression stockings as adjuvant to pharmaco-thromboprophylaxis in elective surgical patients (GAPS study): randomised controlled trial

Joseph Shalhoub, Rebecca Lawton, Jemma Hudson, Christopher Baker, Andrew W. Bradbury et al. (14 authors)

BMJ2020-05-1364 citations

10.1136/bmj.m1309

Interventions

Participants are randomly allocated using a computer to one of two groups. Group 1: Participants are treated with low molecular weight heparin (LMWH) as per standard clinical recommen

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Current inclusion criteria as of 26/04/2018: 1. Aged 18 years or over (from Jan 2018 recruitment will be restricted to patients aged 65 years and above) 2. Capacity to provide informed consent 3. Elective surgical inpatients at a participating hospital 4. Moderate or high risk of venous thromboembolism (VTE) Previous inclusion criteria: 1. Aged 18 years or over 2. Capacity to provide informed consent 3. Elective surgical inpatients at a participating hopsital 4. Moderate or high risk of venous thromboembolism (VTE)

Exclusion criteria

Exclusion criteria: 1. Contraindications to low molecular weight heparin (LMWH) 2. Contraindications to graduated compression stockings (GCS), including peripheral arterial disease, stroke patients, individuals undergoing lower limb surgery 3. Documented or known thrombophilia or thrombogenic disorder 4. Individuals requiring therapeutic anticoagulation 5. Previous venous thromboembolism (VTE) 6. Patients having intermittent pneumatic compression (IPC) beyond theatre and recovery 7. Patients requiring inferior vena cava (IVC) filter 8. Pregnancy 9. Patients requiring extended thromboprophylaxis 10. Application of a cast or brace in theatre

Design outcomes

Primary

Measure	Time frame
Presence of VTE within 90 days of surgery is measured using duplex ultrasound scanning of lower limbs 1, 2-3 weeks and 90 days post surgery.	—

Secondary

Measure	Time frame
1. Compliance with stockings and LMWH is determined at 90 days 2. Overall mortality is determined at 90 days 3. Quality of life is measured using the EQ5D questionnaire at 90 days	—

Countries

England, United Kingdom

Outcome results

None listed