The influence of platelet-rich fibrin on pain, bleeding, swelling, and soft tissue healing after tooth extraction

The influence of platelet-rich fibrin on post-surgical complications following the removal of impacted wisdom teeth

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN13878305

Enrollment

Registered

2020-11-09

Start date

2016-03-15

Completion date

Unknown

Last updated

2022-03-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain following wisdom tooth extraction Oral Health

Interventions

During all the surgical procedures, all the extractions were accomplished by elevating a full-thickness mucoperiosteal flap. Following the reflection of the mucoperiosteal flap in the conventional den

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Presence of unilateral or bilateral premolars or molars indicated for extraction 2. American Society of Anaesthesiologists (ASA) physical status classification; ASA grade I

Exclusion criteria

Exclusion criteria: 1. Pregnant women 2. Patients allergic to penicillin 3. Patients using other medications during the typical follow-up period

Design outcomes

Primary

Measure	Time frame
Measured at 1, 2 and 6 h post-operatively: 1. Pain (Visual Analogue Scale [0 to 5]) 2. Bleeding ((Visual Analogue Scale [0 to 4])	—

Secondary

Measure	Time frame
On days 1, 2, 3, 7 and 15 post-operatively: 1. Swelling, assessed by the surgeon	—

Countries

Saudi Arabia

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026