Premedication for non-urgent endotracheal intubation for preventing pain in neonates with respiratory failure Respiratory
Conditions
Interventions
The research team comprised three research neonatologists, a child health care expert, and three assistants with extensive research and clinical experience. Following the acquisition of informed conse
Sponsors
Children’s Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Children with indications for endotracheal intubation, intravenous access or time to open intravenous access, and able to complete intubation within 15-30 minutes
Exclusion criteria
Exclusion criteria: 1. Children with emergency intubation 2. Structural abnormalities of the upper respiratory tract (e.g. Pierre-Robin syndrome, glottic stenosis) 3. Upper digestive tract malformation (such as diaphragmatic hernia) 4. A history of difficulty in endotracheal intubation 5. Central respiratory failure caused by asphyxia or brain injury 6. Children intubated twice or more during treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Behavioural responses measured using the N-PASS score at the time of intubation 2. Analgesic efficacy measured using plasma neuron-specific enolase (NSE), cortisol and endorphins concentrations in venous blood samples before and after intubation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Conditions of endotracheal intubation (difficulty of intubation, the opening and closing state of the glottis, and the children's response to intubation) evaluated using the modified Goldberg score at the time of intubation 2. Adverse reactions evaluated using heart rate (HR), oxygen saturation (SaO2) and regional cerebral oxygen saturation (rScO2) before and after intubation | — |
Countries
China
Outcome results
None listed