Developing immersive virtual exposures for obsessive-compulsive disorder

Developing immersive virtual exposures for obsessive-compulsive disorder – Protocol for a Randomised, Controlled, Proof-of-Concept Feasibility Trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN13869986

Enrollment

Registered

2025-12-29

Start date

2026-01-05

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obsessive-Compulsive Disorder Mental and Behavioural Disorders

Interventions

3 Arms: AI-generated OCD immersive VR exposure AI-generated OCD-related exposure via widescreen display Neutral immersive VR exposure (control) Arm 1: AI-generated OCD-related immersive VR exposure

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Adults aged 18 to 65 years 2. Primary diagnosis of OCD confirmed by Mini International Neuropsychiatric Interview (MINI 5.0.0) 3. Y-BOCS-II score = 14 (moderate to extremely severe symptoms) 4. At least one OCD subtype amenable to visual exposure (contamination/washing, checking, or symmetry/ordering) 5. Ability to provide informed consent

Exclusion criteria

Exclusion criteria: 1. Predominant OCD symptoms not suitable for visual exposure 2. Current or past psychotic episode, schizophrenia, or autism spectrum disorder 3. Current substance use disorder 4. Self-reported history of severe cardiovascular disease where acute physiological arousal poses a safety risk, defined as the presence of an implanted cardiac device (pacemaker or ICD), a diagnosis of heart failure or aortic aneurysm, or the occurrence of a major cardiac event (myocardial infarction, stroke, or cardiac surgery) within the past 12 months 5. Visual or auditory impairment, motion sickness susceptibility, or epilepsy

Countries

England, Portugal, United Kingdom

Contacts

Public ContactMariana Pinto da Costa

mariana.pintodacosta@kcl.ac.uk+442078480002

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026