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Lidocaine and epinephrine mixture relieves pain from impacted molar surgery

Evaluation of the effectiveness of lidocaine with epinephrine irrigation in reducing acute pain from surgical removal of mesioangular-impacted third molars

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN13866362
Enrollment
34
Registered
2024-10-01
Start date
2015-10-01
Completion date
Unknown
Last updated
2025-01-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Impacted lower mandibular molars Oral Health

Interventions

Participants were randomly divided by block randomization to receive 2% lidocaine or 0.5% bupivacaine post-operatively. Either molar side was randomly selected for the initial surgery and flushed with

Sponsors

Chiang Mai University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Aged between 18 and 25 years 2. Systemically deemed to be healthy 3. Orthodontically indicated for impacted lower third molar on both sides as depicted in panoramic radiographs 4. Non-allergic to amoxicillin and paracetamol 5. Had not previously experienced inflammation or infection of the teeth and gums around the lower molars before treatment

Exclusion criteria

Exclusion criteria: 1. History of neurological disorders 2. Allergies to lidocaine and bupivacaine 3. Received steroid medication

Design outcomes

Primary

MeasureTime frame
1. Duration of surgery and postoperative irrigation volume of NSS or lidocaine plus epinephrine used, recorded after surgery 2. Pain is measured using the visual analogue score (VAS) at baseline, 24, 48 and 72 hours 3. Number of paracetamol consumed, recorded after surgery 4. VAS-aided assessment of pain measured in participants receiving bupivacaine or lidocaine at 2, 4, 6, and 8 hours post-operation

Secondary

MeasureTime frame
There are no secondary outcome measures

Countries

Thailand

Contacts

Public ContactSomdet Srichairatanakool
somdet.s@cmu.ac.th+66 (0)810353463

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 5, 2026