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Using oxygen to improve exercise performance in patients with cystic fibrosis

High-intensity interval training (HIIT) accelerates oxygen uptake kinetics and improves exercise tolerance for individuals with cystic fibrosis – a pilot study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN13864650
Enrollment
11
Registered
2019-07-16
Start date
2009-05-15
Completion date
Unknown
Last updated
2020-11-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cystic fibrosis Nutritional, Metabolic, Endocrine Cystic fibrosis

Interventions

This pilot study employed a randomised, single-blind design. Participants were randomly assigned to a group performing HIIT with O2 supplementation (O2+) or a group performing HIIT while breathing amb

Sponsors

School of Health and Human Performance, Dublin City University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Diagnosis of CF that was based on clinical features, sweat test, or genotyping, and a pulmonary function test 2. Age > 18 years 3. Forced expiratory in one second (FEV1) > 30% predicted 4. Clinically stable

Exclusion criteria

Exclusion criteria: Does not meet inclusion criteria

Design outcomes

Primary

MeasureTime frame
Maximal exercise capacity measured using an incremental symptom-limited peak exercise test on an electronically-braked cycle ergometer while breathing through a full face mask measured at baseline and 12-weeks.

Secondary

MeasureTime frame
1. Anthropometric measurements: height and body mass were measured and double thickness subcutaneous adipose tissue was determined on the right side of the body using skinfold calipers, at the first visit. 2. Pulmonary function tests: spirometry and single-breath carbon monoxide diffusion capacity were measured at the first visit.

Countries

Ireland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 27, 2026