Drinking a solution prior to gastroscopy improves the view

Pre-medication with N-acetylcysteine and simethicone improves mucosal visualisation during gastroscopy: a randomised, controlled, endoscopist-blinded study.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN13858956

Enrollment

Registered

2012-02-28

Start date

2011-04-01

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastrointestinal endoscopy Digestive System

Interventions

Patients attend for gastroscopy having already undergone standard preparation at home (6 hours clear fluids only, 2 hours nil by mouth [NBM]). On entering the study they were randomised (number tabl

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All adult patients attending for clinically required diagnostic gastroscopy

Exclusion criteria

Exclusion criteria: 1. Patients with previous allergic reactions to N-acetylcysteine or simethicone 2. Patients under the age of 18 years old 3. Patients who lack capacity to consent 4. Those patients not medically fit for endoscopy 5. Those patients where it is deemed unsafe to swallow liquids

Design outcomes

Primary

Measure	Time frame
Amount of water required to clear stubborn mucus	—

Secondary

Measure	Time frame
1. Area of GI tract 2. Time taken for procedure	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026