Assessing acute and late developing heart function in patients with sepsis and septic shock with cardiac ultrasound

The assessment of left ventricular function in septic shock; comparison of ejection fraction measurement (both by two dimensional and three dimensional echocardiography), global longitudinal strain, high sensitivity troponin and pro NtBNP.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN13837507

Enrollment

108

Registered

2020-12-07

Start date

2021-04-01

Completion date

Unknown

Last updated

2023-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Left ventricular function in septic shock Circulatory System Left ventricular function in septic shock

Interventions

GLASSheart is a cohort study. Within the first 24 h, the study team will obtain consent to participate and then start to collect demographic and basic physiological data from participants (this data i

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 18-85 years inclusive 2. Sepsis or septic shock (defined by Third International Consensus Definitions for Sepsis and Septic Shock) 3. Admission to the Intensive Care Unit (ICU) 4. Consent to inclusion or favourable opinion for inclusion from consultee

Exclusion criteria

Exclusion criteria: 1. Pregnancy or complications thereof 2. End-Stage Renal Failure (ESRF) requiring dialysis, or Chronic Kidney Disease (CKD) with eGFR <30 ml/min 3. Cardiac transplant recipient 4. Uncorrected valvular dysfunction (graded as moderate or severe) 5. Known structural heart disease 6. Pre-existing cardiomyopathy with bundle block on electrocardiogram (ECG) 7. Previous cardiac valve replacement 8. Post-operative within last 7 days 9. Atrial fibrillation/flutter or frequent ventricular ectopic beats during image acquisition 10. Death likely within 24 h in the opinion of the assessing clinician

Design outcomes

Primary

Measure	Time frame
1. Left ventricular function measured using: 1.1. Echocardiography: two-dimensional ejection fraction calculation (2D EF), three-dimensional ejection fraction (3D EF), and global longitudinal strain (GLS), at 24 h, 72 h, 30 days, and 90 days 1.2. Peripheral venous blood tests to identify troponin (high sensitivity assay- HS TROP), and B-type natriuretic peptides (BNP) at 24 h, 30 days, and 90 days	—

Measure

Time frame

1. Left ventricular function measured using: 1.1. Echocardiography: two-dimensional ejection fraction calculation (2D EF), three-dimensional ejection fraction (3D EF), and global longitudinal strain (GLS), at 24 h, 72 h, 30 days, and 90 days 1.2. Peripheral venous blood tests to identify troponin (high sensitivity assay- HS TROP), and B-type natriuretic peptides (BNP) at 24 h, 30 days, and 90 days

—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

England, United Kingdom

Contacts

Public ContactIan Gedge

Ian.Gedge@porthosp.nhs.uk-

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026