The role of curcumin as a radiosensitiser in patients receiving radiation for head and neck squamous cell cancers and to find its effectiveness in reducing mucositis in patients receiving radiotherapy for head and neck squamous cell cancers

Efficacy of curcumin as a radio-sensitiser and in minimising mucosal damage in patients receiving radiotherapy for head and neck squamous cell cancers

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN13817594

Enrollment

Registered

2017-11-11

Start date

2012-12-10

Completion date

Unknown

Last updated

2020-04-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adjunct to radiotherapy in patients with head and neck squamous cell cancer Cancer Oral carcinoma, Radiation, Chemoradiation, Radiosensitiser, Curcumin, Mucositis

Interventions

Detailed clinical examination are carried out and patients are staged according to AJCC 2012 TNM classification. All adult patients undergoing radiotherapy or concurrent chemo-radiotherapy for Head an

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All adult patients undergoing radiotherapy or concurrent chemo-radiotherapy for Head and Neck Squamous Cell Carcinoma 2. Aged 30- 90 years old

Exclusion criteria

Exclusion criteria: 1. Patients with Non Squamous Head and Neck cancers, patients not giving consent for the treatment 2. Patients with severe acid-peptic disease 3. Patients with distant metastasis 4. Patients with recurrent tumors

Design outcomes

Primary

Measure	Time frame
1. Tumor response is measured using the RECIST criteria using contrast enhanced computerized tomography (CECT) scan at three months 2. Effect of curcumin on oral mucositis is measured using the NCI-CTAE and WHO criteria for mucositis on a weekly basis during treatment and 2 months after treatment for subjective and Objective Assessment respectively	—

Secondary

Measure	Time frame
There are no secondary outcome measures.	—

Countries

India

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026