Glaucoma Eye Diseases Glaucoma
Conditions
Interventions
This cross-sectional, observational, multi-centric study involves acquisition of visual field tests from both normal and glaucomatous subjects using two different perimeters. Each patient enrolled und
Sponsors
CenterVue SpA
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Normal subjects: 1. Age: 18 - 90 years old 2. best corrected visual acuity > 0.8 (if 6/10 (if >50 years old) in study eye 3. Refraction -10D / +6D; astigmatism between - 2D and 2D 4. Normal optic nerve head in both eyes (no evidence of excavation, rim thinning, notching, disc hemorrhages, RNFL thinning); 5. IOP less than 21 mmHg in both eyes 6. No ocular pathologies, trauma, surgeries (apart from uncomplicated cataract surgery) in both eyes 7. Absence of pathologies that can affect visual field 8. No use of drugs interfering with the correct execution of perimetry 9. Should have at least two reliable VF exams (for example one HFA, one Compass) Glaucoma patients: 1. Age: 18 - 90 years old 2. Best corrected visual acuity > 0.8 (if 6/10 (if >50 years old) in study eye; 3. Refraction -10D / +6D; astigmatism between - 2D and 2D 4. Glaucomatous optic nerve head in both eyes (according to the specialist opinion at ophthalmoscopy) and abnormal OCT (ONH and RNFL) 5. Patients under anti-glaucoma therapy 6. No ocular pathologies, trauma, surgeries (apart from uncomplicated cataract surgery) in both eyes 7. Absence of pathologies that can affect visual field other than glaucoma 8. No use of drugs interfering with the correct execution of perimetry or that would produce visual field loss 9. Should have at least two reliable VF exams (for example one HFA, one Compass)
Exclusion criteria
Exclusion criteria: Normal subjects: 1. Age: 90 years old 2. Best corrected visual acuity 50 years old) in study eye 3. Refraction +6D; astigmatism between 2D 4. Abnormal optic nerve head in both eyes ( evidence of excavation, rim thinning, notching, disc hemorrhages, RNFL thinning) 5. IOP > 21 mmHg in both eyes 6. Ocular pathologies, trauma, surgeries (apart from uncomplicated cataract surgery) in both eyes 7. Presence of pathologies that can affect visual field 8. Use of drugs interfering with the correct execution of perimetry 9. Less than two reliable VF exams Glaucomatous subjects: 1. Age: 90 years old 2. Best corrected visual acuity 50 years old) in study eye 3. Refraction +6D; astigmatism between 2D 4. Normal optic nerve head in both eyes (according to the specialist opinion at ophthalmoscopy) and normal OCT (ONH and RNFL) 5. Patient not under anti-glaucoma therapy 6. Ocular pathologies, trauma, surgeries (apart from uncomplicated cataract surgery) in both eyes 7. Presence of pathologies that can affect visual field other than glaucoma 8. Use of drugs interfering with the correct execution of perimetry or that would produce visual field loss 9. Less than two reliable VF exams (for example one HFA, one Compass)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Test-retest variability, assessed by parametric statistical methods, on both normal subjects and subjects with glaucoma. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Sensitivity / specificity of the diagnosis of glaucoma using both perimeters vs. diagnosis from a glaucoma expert using independent data (morphological and functional data) 2. Average test time 3. Age-matched normative database | — |
Countries
Australia, England, Italy, United Kingdom, United States of America
Contacts
Public ContactChiara Rui
Outcome results
None listed