Schools Transmission Study (COVID-19 and scarlet fever)

Schools Transmission Study - COVID-19 and Scarlet Fever

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN13773960

Enrollment

344

Registered

2020-10-22

Start date

2018-03-01

Completion date

Unknown

Last updated

2021-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19 (SARS-CoV-2 infection), Scarlet fever Infections and Infestations COVID-19 (SARS-CoV-2 infection), Scarlet fever

Interventions

Scarlet fever arm: At the time an outbreak of scarlet fever is reported to PHE (and there are at least 2 cases in a cluster): 1. HPT will offer the usual advice to the

an information leaflet and consent form will be supplied, with a request to bring signed form back to school/nursery next day. Age-appropriate leaflets and assent forms for children will also be sent

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. School children aged 2y - 11y (scarlet fever) or 2y - 14y (COVID-19) 2. Notified cases or contacts of cases attending the same school affected by case(s) or school staff or members of Households (any age) affected by case(s) provided consent is obtained

Exclusion criteria

Exclusion criteria: 1. Children who express a strong desire not to participate despite parental consent 2. Those who lack capacity to consent 3. Children aged under 1

Design outcomes

Primary

Measure	Time frame
Measured at the time of outbreak: Scarlet fever arm: 1. Detection of viable group A streptococcus measured by conventional bacterial culture 2.Longevity of group A streptococcal infection/shedding using bacterial culture on repeated days/weeks 3. Genomic evidence confirming or refuting transmission ascertained using genome sequencing and comparative phylogenetic analysis of bacteria identified COVID-19 arm: 1. Detection of SARS-CoV2 RNA measured using quantitative rtPCR; result: Yes or No 2. Viral load of RNA measured by qRTPCR 3. Viability of viral RNA after viral culture measured using Vero Cell culture and assay of RNA increase; result: Yes or No 4. The longevity of SARS-CoV2 infection/RNA shedding measured using quantitative rtPCR and viral culture on repeated days/weeks 5. Total number of contacts (Contacts are school children 2 - 14 years attending the school affected by the Case(s) or school staff or members of Household (any age) affected by Case(s)) 5. Number of contacts with a positive swab 6. Genomic evidence refuting transmission ascertained using genome sequencing and comparative phylogenetic analysis of viruses identified; result: Yes or No	—

Measure

Time frame

Measured at the time of outbreak: Scarlet fever arm: 1. Detection of viable group A streptococcus measured by conventional bacterial culture 2.Longevity of group A streptococcal infection/shedding using bacterial culture on repeated days/weeks 3. Genomic evidence confirming or refuting transmission ascertained using genome sequencing and comparative phylogenetic analysis of bacteria identified COVID-19 arm: 1. Detection of SARS-CoV2 RNA measured using quantitative rtPCR; result: Yes or No 2. Viral load of RNA measured by qRTPCR 3. Viability of viral RNA after viral culture measured using Vero Cell culture and assay of RNA increase; result: Yes or No 4. The longevity of SARS-CoV2 infection/RNA shedding measured using quantitative rtPCR and viral culture on repeated days/weeks 5. Total number of contacts (Contacts are school children 2 - 14 years attending the school affected by the Case(s) or school staff or members of Household (any age) affected by Case(s)) 5. Number of contacts with a positive swab 6. Genomic evidence refuting transmission ascertained using genome sequencing and comparative phylogenetic analysis of viruses identified; result: Yes or No

—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

United Kingdom

Contacts

Public ContactKerri Hill-Cawthorne

k.hill-cawthorne@imperial.ac.uk+44 (0)20 3313 2072

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026