Effect of a ketogenic diet on the memory domain of cognition and its associated biomarkers in healthy individuals

Effect of ketogenic diet on memory domain of cognition and its association biomarkers in healthy individuals: quasi-experimental trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN13729125

Enrollment

108

Registered

2025-09-28

Start date

2021-10-12

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognition parameters in healthy individuals on a ketogenic diet Nutritional, Metabolic, Endocrine

Interventions

For sample size calculation, the power calculation was based on the expected change in the memory function, which is the primary outcome. Sample size was calculated through the OpenEpi sample size cal

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age 25-45 2. BMI 18-29.9 Kg/m2

Exclusion criteria

Exclusion criteria: 1. Diabetes 2. Heart diseases 3. Disorders of fatty acid metabolism 4. Hypertensives 5. Thyroid problems 6. Liver dysfunction 7. Neurodegenerative diseases 8. Obstructive sleep apnea 9. Pregnancy 10. Lactation 11. Keto food allergies

Design outcomes

Primary

Measure	Time frame
Memory was measured using the NIH Toolbox cognition software at baseline and endpoint of the trial	—

Secondary

Measure	Time frame
1. Serum brain-derived neurotrophic factor (BDNF) and cAMP response element-binding protein (CREB) levels were measured using the ELISA kit at baseline and endpoint of the trial 2. Serum MicroRNA 124 and 132 by quantitative PCR at baseline and endpoint of the trial	—

Countries

Pakistan

Contacts

Public ContactMunaza;Muhammad Khattak;Irfan

;

Phys_munazakhattak@prime.edu.pk;Muhammad.irfan@prime.edu.pk+92 03005976937;+923339123625

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026