Infection-related glomerulonephritis Urological and Genital Diseases
Conditions
Interventions
Patients meeting the inclusion criteria are randomized 1:1, in blocks of 4, to receive either standard care (control arm), or standard care plus corticosteroids (intervention arm). Patients randomized
Sponsors
Madras Medical College
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients older than 18 years who provide written informed consent 2. Fulfilment of 3/5 of the Nasr et al. criteria for infection-related glomerulonephritis 3. Serum creatinine >1.5 mg/dl at time of randomisation
Exclusion criteria
Exclusion criteria: 1. More than 21 days elapsed since presentation 2. Presence of a contraindication for steroids 3. Seropositivity for HIV, hepatitis B, or hepatitis C 4. Hypocomplementaemia at 3 months 5. IgA-dominant infection-related glomerulonephritis 6. Crescents involving >50% of the sampled glomeruli 7. Diabetic nephropathy class III or IV 8. Interstitial fibrosis and tubular atrophy >40%
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete remission, defined as an estimated glomerular filtration rate (eGFR) of >60 ml/min/1.73m², assessed at 6 months after randomisation, or at time of last follow-up, whichever is earlier | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Combined complete remission (defined as eGFR >60 mL/min/1.73m² at 6 months) and partial remission (defined as serum creatinine lower than peak creatinine during initial admission, along with eGFR 0.5 or dipstick 2+ or more) at 6 months 4. Dialysis independence at any point within 6 months since randomization, among patients with dialysis-requiring renal failure at initial presentation (taken from the patient's medical records) | — |
Countries
India
Contacts
Public ContactTanuj Lamech
Outcome results
None listed