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To assess the effect of antibiotic eye drops (azithromycin) on the signs and symptoms of dry eyes (Meibomian gland dysfunction)

The Topical Azithromycin Meibomian Gland Dysfunction Survey (TAMS): the effect of topical azithromycin on signs and symptoms of Meibomian gland dysfunction

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN13717543
Enrollment
40
Registered
2023-06-22
Start date
2019-10-02
Completion date
Unknown
Last updated
2024-09-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Meibomian gland dysfunction Eye Diseases

Interventions

This study was conducted in a community Optometry practice over a 2 year period (2016-2018). Patients were invited to participate in the study, who had persistent Meibomian gland dysfunction (MGD) and

Sponsors

University of Dundee
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: This study was conducted in a community Optometry practice over a 2 year period (2016-2018). Patients were invited to participate in the study, who had persistent Meibomian gland dysfunction (MGD) and previous treatment of lid hygiene, lubricants, heat & massage had been ineffective at relieving signs or symptoms.

Exclusion criteria

Exclusion criteria: 1. No Meibomian gland dysfunction 2. Managed Meibomian gland dysfunction

Design outcomes

Primary

MeasureTime frame
1. Meibomian gland dysfunction (MGD) measured using the Efron grading scale before and after treatment 2. Fluorescein tear break up time (FTBUT) measured after instillation of 1% Fluorescein (Bausch & Lomb minims) and measured in seconds, counted by the examiner, before and after treatment

Secondary

MeasureTime frame
Long-term benefit of treatment on symptoms and self-treatment methods, by post-treatment survey one year on from treatment. In brief, the survey asked the participants how their management of MGD had changed, which dry eye symptoms they had pre- and post-treatment (sensitivity to light, gritty/ burning sensation and blurred vision). They were also asked to what extent their symptoms affected their lifestyle, (reading, night driving, computer use and watching television) and how they were affected by environmental conditions (windy, dry and air-conditioned environments). This used a combination of yes/no responses and a numerical grading of symptoms of 1-5, where 1= least affected and 5=most affected.

Countries

Scotland, United Kingdom

Contacts

Public ContactIan Jarvis
ian.jarvis2@nhs.scot+44 1382462236

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026