Kidney transplantation from deceased donors. Surgery
Conditions
Interventions
Prospective kidney transplant recipients on the waiting list at a single centre (Cambridge University Hospitals NHS Foundation Trust), who are eligible to participate in this study, will be approached
Sponsors
University of Cambridge
Cambridge University Hospitals NHS Foundation Trust
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Current inclusion criteria as of 17/06/2025: 1. Patients receiving a kidney from donation after brain death (DBD) and/or donation after circulatory death (DCD) donor =50 years 2. Transplant recipients aged =18 years 3. Patients undergoing a 1st or 2nd kidney transplant 4. Patients who have given written informed consent Previous inclusion criteria: 1. Patients receiving a kidney from donation after brain death (DBD) and/or donation after circulatory death (DCD) donor =50 years 2. Transplant recipients aged =18 years 3. Patients undergoing a 1st or 2nd kidney transplant 4. Patients who have given written informed consent 5. Patients who are receiving renal replacement therapy
Exclusion criteria
Exclusion criteria: Current exclusion criteria as of 17/06/2025: 1. Patient receiving a kidney from DCD and DBD donor <50 years old 2. Patients receiving a 3rd or subsequent kidney transplant 3. Patients receiving multi-organ transplants e.g. simultaneous pancreas-kidney transplantation 4. Patients receiving dual kidney transplants 5. Paediatric en-bloc kidney transplants 6. Kidneys with complex vascular anatomy Previous exclusion criteria: 1. Patient receiving a kidney from DCD and DBD donor <50 years old 2. Patients receiving a 3rd or subsequent kidney transplant 3. Patients receiving multi-organ transplants e.g. simultaneous pancreas-kidney transplantation 4. Patients receiving dual kidney transplants 5. Paediatric en-bloc kidney transplants 6. Patients that are pre-dialysis 7. Kidneys with complex vascular anatomy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inflammatory and immune gene expression measured in cortical biopsy from the kidney 60 minutes post-transplant | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Rates of delayed graft function, defined as the requirement for dialysis in the first 7 days post-transplant 2. Duration of delayed graft function, measured from the first to the last episode of dialysis post-transplant 3. Incidence of primary non function, defined as a non-functioning graft up to 3 months post-transplant 4. Graft function at 3 months post-transplant measured by levels of serum creatinine and estimated glomerular filtration rate (eGFR) 5. Incidences of biopsy-proven rejection measured by histopathology up to 3 months post-transplant 6. Complications (infection, re-operation due to bleeding) recorded up to 3 months post-transplant 7. The length of hospital stay post-transplant 8. Levels of inflammation/immune and injury markers measured in the perfusate and urine collected from the kidney during NMP (pre, 2, 4 and 6 h). Samples will be analysed using ELISA techniques 9. Isolation of peripheral blood mononuclear cells blood samples collected pre-transplant and on day 1 and day 5 post-transplant 10. Biomarkers of kidney injury measured by ELISA using plasma samples collected from the patients on day 1 and day 5 post-transplant | — |
Countries
England, United Kingdom
Contacts
Public ContactSarah Hosgood
Outcome results
None listed